Two-piece capsules have been used for almost a century in the pharmaceutical field, and gelatin has been adopted as the main material of these capsules due to its excellent characteristic as a gelatinizer. The gelatin dissolves under high concentration into water of a high temperature and quickly gels in room temperature. The thickness of the film made by the gelatin becomes uniform. However, gelatin is one of the proteins derived from animals; therefore, it is unstable from a chemical viewpoint and has a risk of TSE. Several materials have been examined as a substitute for the gelatin in two-piece hard capsules. Hydroxypropylmethyl cellulose (HPMC) has now become a successful alternative material for two-piece capsules, overcoming the animal source and being suitable for vegetarians. HPMC has also been adopted as a film coating or a sustained-release tablet material in the pharmaceutical field. HPMC capsules have been developed for both pharmaceutical products and dietary supplements.
Hydroxypropyl methyl cellulose (HPMC; CAS No. 9004-65-3) is an odorless and tasteless, white to slightly off-white, fibrous or granular, free-flowing powder that is a synthetic modification of the natural polymer, cellulose.
ProTec HPMC Capsules are exclusively sourced and supplied by ProTec Nutra Ltd. Our high quality capsules are produced at a state-of-the-art manufacturing facility. The range covers Hard Cellulose Capsule Shells for vegetarian use.
Our capsules are produced to the highest quality standards, including cGMP and cGLP practices. Our team has almost 20 years experience of working with 2-piece Capsule technologies, and they have more recently achieved compliance for pharmaceutical use.
We’re confident our capsules will run on your machines and samples can be made available for trials. Clear capsules, in sizes #1, #0 and #00 are generally available from stock.
Coloured capsules are available to order and a capsule printing service can also be provided. Opaque white #00 HPMC capsules are now available from stock.